Melchor de la Barrera was the son of Juan Barrera and Beatriz Rodriguez.
He married Mariana Treviño Navarro.
Juana de la Barrera married Antonio Montes de Oca.
Beatriz de la Barrera married Joseph Montalvo.
Ana Maria de la Barrera was born circa 1655. She married Tomas Sanchez Duran.