He married Mariana Treviño Navarro, daughter of Alonso Treviño de la Garza and Anastacia Gonzalez Hidalgo.
Ana Estacia (Anastacia) de la Barrera. She married Pedro Rodriguez on 30 Sep 1667 in Monterrey.
Juana de la Barrera. On 26 Dec 1681, she requested a dispensation to marry Antonio Montes de Oca in Monterrey due to 4th degree blood relation.
Beatriz de la Barrera. She married Joseph Montalvo, son of Pasqual de Montalvo and Maria Rangel.
Ana Maria de la Barrera, born 1655. She married Tomas Sanchez Duran, son of Francisco Sanchez de la Barrera and Maria Duran.
He died on 13 Jan 1678.