She was born circa 1777. Her father was Gregorio Guadiana, and her mother was Maria Antonia Ramos. In 1782, she lived in Mier in household number 33. The church census recorded that she was a young child, española, and 5 years old. Her household included 6 people. In 1791, she lived in Mier in household number 44. The church census recorded that she was an unmarried girl, española, and 14 years old. Her household included 7 people.
She married Jose Cayetano Gonzalez, son of Jose Alonzo Gonzalez and Maria Guadalupe Garcia on 8 Jul 1795. She was 18 years old, and the groom was 19 years old.