He was born circa 1550. His father was Gaspar de Ayala, and his mother was Maria de Valverde.
He married Mariana de Guevara Estrada, daughter of Juan Alonso de Estrada and Mariana de Guevara y de Barrios.
Leonor de Ayala Valverde, born 1580. She married Joseph de Treviño, son of Jose Diego de Tremiño and Beatriz de Quintanilla. Her husband died in 1651 in Monterrey. He was 86 years old.